PK assays help to select the dose for preclinical and clinical studies. Pharmacokinetic (PK) assays are used by pharmaceutical companies that want to understand the absorption, distribution, metabolism and excretion characteristics of chemical compounds. PK data allows companies to establish the dose for preclinical and clinical studies. During method validation, all factors that can possibly influence the validity of the data generated by the assay are taken into consideration. Scientists have to be clear on the ability of the assay to identify the drug in the sample matrix.
PK assays help in comparative analysis of originator and biosimilar products. The assays are used for the detection of monoclonal antibodies using anti-idiotypic antibodies. They are established and validated for therapeutic proteins with endogenous counterparts. The scientists have to distinguish the recombinant and endogenous protein. This helps in drug discovery and optimization process. Patients of today and tomorrow are at an advantage. They now enjoy a better quality of life. The advancements in pharmacokinetic lead to better drug that are easily absorbed by the body to treat patients of various life threatening diseases. The research and new creations extend the lifespan of humans. Drug discovery methods lead to creation of better drugs. Instead of taking four to five types of medicines that interact with each other in negative or positive ways, they can take only one. The body influences the absorption of drugs and discovering it leads to new drugs. Pharmaceuticals aim to enhance drug discovery and optimization using organic compounds which are small organic molecules and biologics. Computer aided drug designing is also making advancements. It is speeding up progress in biochemistry, molecular, and cell biology for speedy design and creation of new medicines. Research labs help with drug discovery by providing in vitro and in vivo contract research services. For research data on PK assays, click here: http://www.alliancepharmaco.com/ DMPK CRO takes the burden of research work off a company’s shoulder. Today, medical sciences are very advanced and in a stage of specialization. Labs that are fully geared up with the latest software, instrumentation, and expertise are a viable choice as compared to investing millions of dollars on a research facility of your own. Outsourcing the work to a CRO is the best solution these days.
It is not possible for all pharmaceuticals to have their own research labs for the drug discovery process. The contract research organizations have highly skilled technicians that have hundreds of SOPs in place. They conduct their research and analysis work keeping the standards and regulations in focus. Labs that take on contract work are able to follow the methodology of their clients. They can also develop new methods based on your specific requirements. Throughout the research, the clients are kept appraised of the latest developments taking place with their research orders. The labs have cold storage that allows multiple temperatures for storing dozens of chemical samples of various types. When companies need support in developing new types of medicine, they have to study all aspects linked with drug metabolism and pharmacokinetics. The CRO is able to prepare study protocols, schedule resources such as staff and equipment, collate and interpret data, and write reports. Full evaluation of the new chemical entities is delivered to clients in a timely manner. You may ask for complete in vitro and in vivo metabolism data packages for new chemical entities (NCEs), or older products for updated information. Alliance Pharma provides a cost-effective ADME package to speed up your drug discovery and optimization, thus saving you resources on clinical development. For DPMK the following technology platforms are used: · In Vitro Enzyme · Cell Based Assays · LC-MS/MS Technology For DMPK CRO, click here: http://www.alliancepharmaco.com/ |
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